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RNF11 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 16948-1-AP-20UL
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Description
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ′Lys-63′ polyubiquitin chains on RIPK1 and catalyzes the formation of ′Lys-48′-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.Spécification
| RNF11 | |
| Polyclonal | |
| Unconjugated | |
| RNF11 | |
| CGI 123, ring finger protein 11, RNF11, SID1669 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 26994, 29864, 689577 | |
| -20°C | |
| Liquid |
| Immunoprecipitation, Western Blot | |
| 0.17 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| Q9QYK7, Q9Y3C5 | |
| Rnf11 | |
| RNF11 Fusion Protein Ag10563 | |
| 20 μL | |
| Primary | |
| Human, Rat, Mouse | |
| Antibody | |
| IgG |