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USP19 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 25768-1-AP-150UL
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Description
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5′-region of the RUNX1 (AML1) gene fused to the 3′-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.Spécification
USP19 | |
Polyclonal | |
Unconjugated | |
USP19 | |
Deubiquitinating enzyme 19, KIAA0891, Ubiquitin thiolesterase 19, USP19, ZMYND9 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
10869 | |
-20°C | |
Liquid |
Immunoprecipitation, Western Blot | |
0.35 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
O94966 | |
USP19 | |
USP19 Fusion Protein Ag22646 | |
150 μL | |
Primary | |
Human | |
Antibody | |
IgG |