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Thermo Scientific Chemicals U-73122, 95 %
Description
It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Spécification
Spécification
| Quantité | 1 mg |
| Description | Off-white |
| À utiliser avec (application) | Inhibiteur de l’activation de la phospholipase C et inhibe la régulation descendante des récepteurs muscariniques |
| Doser | ≥99% |
| Poids de la formule | 464.65g/mol |
| Solubilité | Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml; May require heating or overnight mixing; Insoluble in water |
| Type de produit | Signal Transduction Reagent |
| Forme | Solide cristallin |
| Clé InChI | LUFAORPFSVMJIW-ZRJUGLEFSA-N |
| SMILES | COC1=CC=C2[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CCC2=C1)NCCCCCCN1C(=O)C=CC1=O |
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RUO – Research Use Only