SS18 Polyclonal Antibody, Invitrogen™

Description

Immunogen sequence: NGQMPGPNHM PMQGPGPNQL NMTNSSMNMP SSSHGSMGGY NHSVPSSQSM P Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

The transcriptional coactivator SYT (synovial translocation protein) contains a conserved amino terminal SNH domain and a carboxy terminal QPGY domain, which is a functioning transcriptional activating sequence. Synovial sarcoma translocation (SSX) proteins, including SSX1-5, are transcriptional repressors that contain a repressor domain in their carboxy termini. SSX proteins are localized to the nucleus and expressed in testis and several types of cancers and, therefore, they are classified as C/T (cancer/testis) antigens. The t(x;18) translocation results in the fusion of the amino terminus of SYT to the carboxy terminus of either SSX1 or SSX2; both fusions result in the production of transcriptional activators.