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MIB1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marque: Invitrogen PA553924
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Description
Immunogen sequence: LDLEIVQSLQ HGHGGWTDGM FETLTTTGTV CGIDEDHDIV VQYPSGNRWT FNPAVLTKAN IVRSGDAAQG AEGGTSQFQV GDLVQVCYDL ERIKLLQRGH GEWAEAM Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Spécification
| MIB1 | |
| Polyclonal | |
| Unconjugated | |
| MIB1 | |
| DAPK-interacting protein 1; DAPK-interacting protein-1; DIP1; DIP-1; E3 ubiquitin-protein ligase MIB1; E430019M12Rik; KIAA1323; LVNC7; MIB; MIB1; Mind bomb homolog 1; mind bomb-1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; mindbomb homolog 1 (Drosophila); mKIAA1323; RING-type E3 ubiquitin transferase MIB1; skeletrophin; ubiquitin ligase mind bomb; zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 57534 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q86YT6 | |
| MIB1 | |
| Recombinant protein corresponding to Human MIB1 | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
Research Use Only