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CISD2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 13318-1-AP-20UL
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Description
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.Spécification
| CISD2 | |
| Polyclonal | |
| Unconjugated | |
| CISD2 | |
| CDGSH iron sulfur domain 2, CDGSH2, CISD2, ERIS, Miner1, MitoNEET related 1 protein, NAF 1, WFS2, ZCD2 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 295457, 493856, 67006 | |
| -20°C | |
| Liquid |
| Immunoprecipitation, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 0.35 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q8N5K1, Q9CQB5 | |
| CISD2 | |
| CISD2 Fusion Protein Ag4172 | |
| 20 μL | |
| Primary | |
| Rat, Mouse, Human | |
| Antibody | |
| IgG |