EEF1B2 Polyclonal Antibody, Invitrogen™

Description

Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, mouse brain. Predicted reactivity: Mouse (96%), Rat (95%), Zebrafish (85%), Xenopus laevis (84%), Pig (98%), Rabbit (99%), Chicken (100%), Rhesus Monkey (100%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

EF-1 (elongation factor-1) is a multi-protein complex that is responsible forthe delivery of aminoacyl-tRNAs to the ribosome. The EF-1 protein complexis composed of four subunits: EF-1 α, EF-1 β, EF-1 δ and EF-1 γ. EF-1 β is a225 amino acid member of the EF-1 β/EF-1 δ protein family and contains oneGST C-terminal domain. Both EF-1 β and EF-1 δ stimulate the exchange ofGDP bound to EF-1 α to GTP. Phosphorylation of EF-1 β affects the GDP/GTP exchange rate. Alternative splicing events of the gene that encodes EF-1 β result in three transcript variants that differ only in the 5' UTR.