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E-cadherin Monoclonal Antibody (NCH-38), Invitrogen™

Mouse Monoclonal Antibody

Marque:  Invitrogen MA512547

Code produit. 11354663

  • 520.00€ / 500µL

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Description

Description

MA5-12547 targets E-Cadherin in IHC (P) applications and shows reactivity with Human samples. The MA5-12547 immunogen is e-cadherin and GST recombinant protein.

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
TRUSTED_SUSTAINABILITY
Spécification

Spécification

E-cadherin
Monoclonal
Conc. Not Determined
tissue culture supernatant with 0.09% sodium azide
P09803, P12830
CDH1
E-cadherin and GST recombinant protein
RUO
12550, 999
4° C
Liquid
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
NCH-38
Unconjugated
CDH1
AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
Mouse
500 μL
Primary
Human, Mouse
Antibody
IgG1 κ
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