DLC1 Polyclonal Antibody, Invitrogen™

Description

Recommended positive controls: H1299, HeLaS3, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (100%), Dog (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a GTPase-activating protein that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.