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Calreticulin Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marque: Invitrogen PA534786
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Description
Recommended positive controls: 293T, A431, HeLa, HepG2, A375, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2. Predicted reactivity: Mouse (94%), Rat (94%), Zebrafish (82%), Xenopus laevis (83%), Pig (94%), Rabbit (95%), Rhesus Monkey (100%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.
Spécification
| Calreticulin | |
| Polyclonal | |
| Unconjugated | |
| CALR | |
| Autoantigen RO; CABP3; CALBP; calcium-binding protein 3; CALR; calrectulin; calregulin; Calreticulin; calreticulin precursor; cC1qR; CRP55; CRT; CRTC; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; HEL-S-99n; I79_008346; RO; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin); SSA | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 12317, 64202, 811 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 0.2 mg/mL | |
| PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7 | |
| P14211, P18418, P27797 | |
| CALR | |
| Recombinant fragment corresponding to a region within amino acids 1 and 214 of Calreticulin (Uniprot ID#P27797) | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |