Water Determination by Karl Fischer Titration in Pharmaceutical Applications

Agenda

Karl Fischer titration (KFT) is the preferred technique for water determination due to its superior accuracy, increased speed and selectivity, and practical advantages over other methods. Today, however, the lack of skilled chemists with experience using the KFT technique can undermine its effectiveness and the quality of results. This situation can have serious consequences in the (bio)pharmaceutical field where water content impacts drug stability, crystal structure, powder flow, dissolution rate, and polymer film permeability in solid dosage forms. It can also lead to growth of microorganisms if unchecked. Errors in analysis often result in costly production stoppages and health risks.

Webinar key topics:

Join this webinar and learn how Hydranal™, Honeywell’s Karl Fischer titration product line, focuses on optimizing the water determination workflow on following steps:

1. Instrument and reagent setup in volumetry and coulometry with suitable drying agents
2. System calibration with reference materials and certified reference materials (CRMs)
3. Sample preparation, analysis and method adaptation with special media, solublizers and buffers
4. Results validation with water standards